Nedrud J, Sigmund N, Brunschwig E, Lamm M
Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA.
Adv Exp Med Biol. 1995;371B:1595-8.
The results presented here extend our previous observations regarding oral immunization against respiratory viruses in three areas. First, from an experiment comparing Sendai virus with influenza virus it appears that the nature of the antigen as well as host-parasite interactions may play an important role in efficiency of oral immunization. Second, oral immunization with an inactivated virus can apparently induce a cell-mediated immune response. Preliminary evidence (not shown) indicated that the magnitude of effector cell killing versus virus-infected target cells was positively influenced by including cholera toxin in the oral immunization regimen. This is consistent with a recent report that cholera toxin could enhance T cell proliferative response to co-fed KLH. Finally, we have shown that oral immunization with inactivated virus plus cholera toxin combined with intranasal inactivated virus boosting, can protect mice from infection for nearly two years--their normal life span.
本文展示的结果在三个方面扩展了我们之前关于针对呼吸道病毒进行口服免疫的观察结果。第一，通过一项比较仙台病毒和流感病毒的实验表明，抗原的性质以及宿主与病原体的相互作用可能在口服免疫的效率中发挥重要作用。第二，用灭活病毒进行口服免疫显然可以诱导细胞介导的免疫反应。初步证据（未展示）表明，在口服免疫方案中加入霍乱毒素对效应细胞杀伤病毒感染靶细胞的程度有积极影响。这与最近一份报告一致，该报告指出霍乱毒素可以增强对共同投喂的钥孔戚血蓝蛋白的T细胞增殖反应。最后，我们已经表明，用灭活病毒加霍乱毒素进行口服免疫并结合鼻内灭活病毒加强免疫，可以保护小鼠免受感染近两年——这接近它们的正常寿命。
