Sato S, Kato S, Arisaka Y, Takahashi H, Tomoike H
First Department of Internal Medicine, Yamagata University School of Medicine, Japan.
Eur Respir J. 1994 Jul;7(7):1294-9. doi: 10.1183/09031936.94.07071294.
The purpose of this paper was to study pulmonary haemodynamics in an elastase-induced emphysema model in awake rats (Group-EL, n = 9) in comparison with saline-treated controls (Group-C, n = 12). Four weeks before haemodynamic study, porcine pancreatic elastase and normal saline were intratracheally instilled in Group-EL and Group-C, respectively. Indwelling pulmonary artery and abdominal aortic catheters were positioned two days before the haemodynamic study. Breathing room air, mean pulmonary artery pressure (Ppa) tended to be higher in Group-EL than in Group-C, although the difference was not statistically significant. Systemic pressure, total systemic vascular resistance and cardiac index did not differ between groups. When exposed to 10% O2, Ppa and pulmonary vascular resistance (PVR) of both groups rose significantly. The increase of Ppa, (but not PVR) in Group-EL during hypoxia was significantly higher than that in Group-C. The magnitude of hypoxic pulmonary vasoconstriction (HPV) tended to be larger in Group-EL than in Group-C. Right ventricles of Group-EL were more hypertrophic than those of Group-C, suggesting a period of higher pulmonary artery pressure than for Group-C. The present results imply that the pressor response of pulmonary vasculature to acute alveolar hypoxia is possibly enhanced in awake rats upon examination four weeks after elastase treatment.
本文旨在研究清醒大鼠弹性蛋白酶诱导的肺气肿模型（EL组，n = 9）与生理盐水处理的对照组（C组，n = 12）的肺血流动力学。在进行血流动力学研究前四周，分别向EL组和C组气管内滴注猪胰弹性蛋白酶和生理盐水。在血流动力学研究前两天放置肺动脉和腹主动脉留置导管。在呼吸室内空气时，EL组的平均肺动脉压（Ppa）虽高于C组，但差异无统计学意义。两组间的体循环压力、总体循环血管阻力和心脏指数无差异。当暴露于10%氧气时，两组的Ppa和肺血管阻力（PVR）均显著升高。低氧期间EL组的Ppa升高幅度（而非PVR）显著高于C组。EL组的低氧性肺血管收缩（HPV）程度倾向于大于C组。EL组的右心室比C组的更肥厚，提示其肺动脉压高于C组的时间更长。目前的结果表明，弹性蛋白酶处理四周后进行检查时，清醒大鼠肺血管对急性肺泡低氧的升压反应可能增强。
