Klijanienko J, el-Naggar A, De Braud F, Micheau C, Janot F, Luboinski B, Gentile A, Russo A, Cvitkovic E
Institut Gustave-Roussy, Villejuif, France.
Anal Quant Cytol Histol. 1993 Oct;15(5):335-40.
One hundred forty-one head and neck squamous cell carcinomas were analyzed for keratin (K) 6, 13 and 19. Staining was evaluated by light microscopy (with or without grading) and image analyzer and expressed as a percentage of positive versus all tumor surface (PSA). Both techniques rendered strongly correlated results. Strong expression was noted in 108 carcinomas (76.1%) for K6, in 18 (12.7%) for K19 and in 21 (14.8%) for K13 (P = .001). One hundred thirty-six (96%) tumors were positive for K6, and their PSA ranged from 0.6% to 48.8%; K19, 48 cases (0.2-44%); K13, 59 (0.2-38.1%). Expression of K6 was related to differentiation. K19 was expressed mainly in moderately and poorly differentiated tumors, and K13 was manifest more in well-differentiated carcinomas or in keratinized areas of less-differentiated ones. Nineteen (13.38%) tumors were positive for both K13 and K19. K19 thus was related to tumor progression and K13 to differentiation. There was no correlation with tumor site or TNM category.
对141例头颈部鳞状细胞癌进行了角蛋白（K）6、13和19的分析。通过光学显微镜（有或无分级）和图像分析仪评估染色情况，并以阳性与所有肿瘤表面的百分比（PSA）表示。两种技术得出的结果高度相关。108例癌（76.1%）K6呈强表达，18例（12.7%）K19呈强表达，21例（14.8%）K13呈强表达（P = 0.001）。136例（96%）肿瘤K6呈阳性，其PSA范围为0.6%至48.8%；K19，48例（0.2 - 44%）；K13，59例（0.2 - 38.1%）。K6的表达与分化有关。K19主要在中分化和低分化肿瘤中表达，K13在高分化癌或低分化癌的角化区域中表达更为明显。19例（13.38%）肿瘤K13和K19均呈阳性。因此，K19与肿瘤进展有关，K13与分化有关。与肿瘤部位或TNM分期无关。
