Cordova A, Navas F J, Escanero J F
Department of Physiology and Biochemistry, University of Valladolid, School of Physiotherapy, Soria, Spain.
Biol Trace Elem Res. 1993 Oct;39(1):13-20. doi: 10.1007/BF02783805.
This study evaluates the consequences of a session of intensive short-duration exercise and Zn supplementation on different hematological variables. Forty male Wistar rats were divided into four groups (n = 10): the first nonsupplemented, maintained at rest (R); the second nonsupplemented, undergoing exercise (E); the third supplemented with Zn, kept at rest (ZnR); and the fourth supplemented with Zn, undergoing exercise (ZnE). Zinc supplements (200 ppm) were given in drinking water. The exercise consisted of a single session of swimming until exhaustion. At rest, RBC, Hb, and Hto fell (p < 0.05), whereas red cell indices, MCV, and MCH rose (p < 0.05) in +ZnR compared with R; MCHC remained unchanged (ZnR vs R). After exercise, RBC, Hb, and Hto increased significantly in E and in ZnE compared with R and ZnR, respectively. In addition, RBC and Hb were lower (p < 0.01) in ZnE compared with E; however, MCV and MCH were higher (p < 0.05) in the group ZnE vs E. With respect to white blood cells--leukocytes (WBC), lymphocytes (LYMPH), and neutrophils (NEUT)--no significant differences were observed between groups at rest (ZnR vs R). WBC and LYMPH increased significantly in E with respect to the rest situation (E vs R), but this did not happen in supplemented animals (ZnE vs ZnR). Level of pH decreased after exercise both in E and in ZnE, but the fall was lower in the latter. We believe that a single session of swimming until exhaustion leads to an increase in RBC, Hb, and Hto without causing changes in MCV, MCH, and MCHC.(ABSTRACT TRUNCATED AT 250 WORDS)
本研究评估了短期高强度运动和补充锌对不同血液学变量的影响。将40只雄性Wistar大鼠分为四组（n = 10）：第一组不补充锌，保持静止（R）；第二组不补充锌，进行运动（E）；第三组补充锌，保持静止（ZnR）；第四组补充锌，进行运动（ZnE）。通过饮用水给予锌补充剂（200 ppm）。运动包括单次游泳直至疲惫。静止时，与R组相比，+ZnR组的红细胞（RBC）、血红蛋白（Hb）和血细胞比容（Hto）下降（p < 0.05），而红细胞指数、平均红细胞体积（MCV）和平均红细胞血红蛋白含量（MCH）升高（p < 0.05）；平均红细胞血红蛋白浓度（MCHC）保持不变（ZnR与R相比）。运动后，与R组和ZnR组相比，E组和ZnE组的RBC、Hb和Hto分别显著增加。此外，ZnE组的RBC和Hb低于E组（p < 0.01）；然而，ZnE组的MCV和MCH高于E组（p < 0.05）。关于白细胞——白细胞（WBC）、淋巴细胞（LYMPH）和中性粒细胞（NEUT）——静止时各组之间未观察到显著差异（ZnR与R相比）。与静止状态相比，E组的WBC和LYMPH显著增加（E与R相比），但补充锌的动物中未出现这种情况（ZnE与ZnR相比）。E组和ZnE组运动后的pH值均下降，但后者的下降幅度较小。我们认为，单次游泳直至疲惫会导致RBC、Hb和Hto增加，而不会引起MCV、MCH和MCHC的变化。（摘要截选至250字）
