Diglisic G, Xiao S Y, Gligic A, Obradovic M, Stojanovic R, Velimirovic D, Lukac V, Rossi C A, LeDuc J W
US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland.
J Infect Dis. 1994 Jan;169(1):204-7. doi: 10.1093/infdis/169.1.204.
An outbreak of severe hemorrhagic fever with renal syndrome (HFRS) occurred in 1988 in Pozarevac, Serbia, Yugoslavia. The disease was diagnosed in 4 children and 1 adult, and 1 of the children died. Rodents were captured from the same area and virus isolation attempted. A hantavirus, POZ-M1, was isolated from lung tissues of hantavirus antigen-positive Mus musculus. Serology and restriction enzyme digestion of polymerase chain reaction-amplified segments from this virus showed that it was a strain of Puumala (PUU) virus, the causative agent of nephropathia epidemica. While Clethrionomys glareolus is the major rodent host for PUU virus, these results suggest that M. musculus may also play an important role in harboring and transmitting PUU-like viruses. The serologic association of this virus with patients with severe HFRS reaffirms that PUU-like viruses may cause severe disease in addition to the generally mild form normally associated with nephropathia epidemica.
1988年，南斯拉夫塞尔维亚的波扎雷瓦茨爆发了肾综合征出血热（HFRS）疫情。4名儿童和1名成人被诊断出患有该疾病，其中1名儿童死亡。从同一地区捕获了啮齿动物并尝试进行病毒分离。从汉坦病毒抗原阳性小家鼠的肺组织中分离出一种汉坦病毒，即POZ-M1。对该病毒进行的血清学检测以及聚合酶链反应扩增片段的限制性酶切分析表明，它是普马拉（PUU）病毒的一个毒株，而普马拉病毒是流行性肾病的病原体。虽然棕背䶄是PUU病毒的主要啮齿动物宿主，但这些结果表明小家鼠在携带和传播类似PUU的病毒方面可能也发挥着重要作用。这种病毒与重症HFRS患者的血清学关联再次证实，除了通常与流行性肾病相关的一般较轻形式外，类似PUU的病毒可能会导致严重疾病。
