台湾原发性胆汁性肝硬化患者中乙肝病毒和丙肝病毒感染的低流行率：一项病例对照研究。

Low prevalences of HBV and HCV infection in patients with primary biliary cirrhosis in Taiwan: a case control study.

作者信息

Chien R N, Sheen I S, Liaw Y F

机构信息

Liver Unit, Chang Gung Memorial Hospital, Chang Gung Medical College, Taipei, Taiwan.

出版信息

J Gastroenterol Hepatol. 1993 Nov-Dec;8(6):574-6. doi: 10.1111/j.1440-1746.1993.tb01655.x.

DOI:10.1111/j.1440-1746.1993.tb01655.x

PMID:7506585

Abstract

To study the role of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection in patients with primary biliary cirrhosis (PBC) against the background of HBV and HCV infection in the general population, serum specimens from a consecutive series of 27 patients with PBC and 108 age/sex matched 'healthy subjects' as control group were submitted to assays for hepatitis B surface antigen (HBsAg), antibody to hepatitis B core antigen (anti-HBc), antibody to hepatitis B surface antigen (anti-HBs) and antibodies to hepatitis C virus (anti-HCV). None of the patients with PBC were HBsAg or anti-HCV positive while 17 (15.7%) and 6 (5.6%) of 'healthy' controls were HBsAg positive and anti-HCV positive (P = 0.017 and 0.26). Patients with PBC also had a significantly lower prevalence of HBV infection than matched controls (70.4% vs 88.9%, P = 0.022). The results suggest that neither HBV nor HCV plays any significant role in the pathogenesis of PBC, and that PBC would not develop or be masked in patients with HBV or HCV infection.

摘要

为了在一般人群中HBV和HCV感染的背景下，研究乙型肝炎病毒（HBV）和丙型肝炎病毒（HCV）感染在原发性胆汁性肝硬化（PBC）患者中的作用，我们将连续收集的27例PBC患者及108例年龄/性别匹配的“健康受试者”作为对照组的血清标本，进行了乙型肝炎表面抗原（HBsAg）、乙型肝炎核心抗原抗体（抗-HBc）、乙型肝炎表面抗原抗体（抗-HBs）及丙型肝炎病毒抗体（抗-HCV）检测。PBC患者中无HBsAg或抗-HCV阳性者，而“健康”对照组中有17例（15.7%）HBsAg阳性，6例（5.6%）抗-HCV阳性（P = 0.017和0.26）。PBC患者HBV感染率也显著低于匹配的对照组（70.4%对88.9%，P = 0.022）。结果表明，HBV和HCV在PBC发病机制中均未起任何显著作用，且HBV或HCV感染患者不会发生PBC或其症状被掩盖。