Akdaş A, Türkeri L, Alican Y, Simşek F, Akoğlu T
Department of Urology, Marmara University School of Medicine, Istanbul, Turkey.
Prostate. 1994;24(3):111-3. doi: 10.1002/pros.2990240302.
Human leukocyte antigens (HLA) are cell surface glycoproteins that have a significant role in the immune system. In some cancers, changes in major histocompatibility complex (MHC) class I and II expression, usually a reduction or loss of these molecules, appear to provide a mechanism whereby tumor cells may escape host immunity. HLA analysis in patients with advanced adenocarcinoma of the prostate revealed the antigens with the highest relative risk factors as DRw52, DRw53, Bw73, DR2, and B5(51). As a result, determination of HLA haplotypes may prove to be useful in determining the men with a higher risk of developing prostate cancer.
人类白细胞抗原（HLA）是细胞表面糖蛋白，在免疫系统中发挥重要作用。在某些癌症中，主要组织相容性复合体（MHC）I类和II类分子表达的变化，通常是这些分子的减少或缺失，似乎为肿瘤细胞逃避宿主免疫提供了一种机制。对晚期前列腺腺癌患者的HLA分析显示，相对风险因素最高的抗原为DRw52、DRw53、Bw73、DR2和B5(51)。因此，确定HLA单倍型可能有助于确定患前列腺癌风险较高的男性。
