伴有多克隆B细胞大量共同浸润的皮肤T细胞淋巴瘤。

Cutaneous T-cell lymphoma with massive co-infiltration of polyclonal B cells.

作者信息

Yagi H, Ogai M, Izumi T, Ebihara T, Sugiura M, Tokura Y, Takigawa M

机构信息

Department of Dermatology, Hamamatsu University School of Medicine, Japan.

出版信息

Br J Dermatol. 1994 Feb;130(2):226-30. doi: 10.1111/j.1365-2133.1994.tb02905.x.

DOI:10.1111/j.1365-2133.1994.tb02905.x

PMID:7510123

Abstract

A 76-year-old man presented with a 3-month history of a cutaneous nodule on the right thigh. The tumour was composed of CD3+, large atypical cells, and CD20+, small normal-appearing cells. Flow cytometry showed that CD20+ cells outnumbered CD3+ cells. By Southern blot hybridization analyses, the malignant cells were shown to be of T-cell origin, because of the presence of rearranged bands for the beta chain of the T-cell receptor, but not for the immunoglobulin heavy chain. This case represents a T-cell lymphoma intermingled with a large number of non-neoplastic B cells.

摘要

一名76岁男性患者，右大腿出现一个皮肤结节，病史3个月。肿瘤由CD3阳性的大的非典型细胞和CD20阳性的外观正常的小细胞组成。流式细胞术显示CD20阳性细胞数量超过CD3阳性细胞。通过Southern印迹杂交分析，由于存在T细胞受体β链的重排条带，而免疫球蛋白重链没有，表明恶性细胞起源于T细胞。该病例为一种T细胞淋巴瘤，混有大量非肿瘤性B细胞。