Matsuoka L Y
Department of Dermatology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA.
J Am Acad Dermatol. 1995 Feb;32(2 Pt 2):361-3. doi: 10.1016/0190-9622(95)90404-2.
We performed immunohistologic studies on a 75-year-old white woman with erythema nodosum (EN) and a systemic lymphoma. A skin biopsy specimen from an EN lesion showed lobular and septal pannicular infiltration by atypical lymphocytes. The cutaneous lymphocytic infiltrate was composed of a monoclonal population of B cells with lambda light chains. Atypical lymphocytes were also seen in the peripheral blood, and flow cytometry showed a predominance of the same phenotype of B cells with lambda light chains. Chemotherapy for systemic B-cell lymphoma resulted in the simultaneous resolution of EN and the lymphoma. This is the first documentation of EN representing direct cutaneous invasion by a B-cell lymphoma.
我们对一名患有结节性红斑（EN）和系统性淋巴瘤的75岁白人女性进行了免疫组织学研究。取自EN病变处的皮肤活检标本显示非典型淋巴细胞呈小叶状和间隔性脂膜炎浸润。皮肤淋巴细胞浸润由具有λ轻链的B细胞单克隆群体组成。外周血中也可见非典型淋巴细胞，流式细胞术显示具有λ轻链的B细胞表型占优势。系统性B细胞淋巴瘤的化疗导致EN和淋巴瘤同时消退。这是关于EN代表B细胞淋巴瘤直接皮肤浸润的首次记录。
