Rice J T, Dick J W, Bierer B W
Poult Sci. 1978 Nov;57(6):1514-8. doi: 10.3382/ps.0571514.
The immunogenic responses to various routes of vaccination of broiler-type chickens to the Clemson University strain of Pasteurella multocida were evaluated. Broilers were vaccinated at 9 or 10 weeks of age using the oral (drinking water), palatine cleft, ocular, or subcutaneous injection routes. All birds were challenged at 11 or 12 weeks of age with virulent X-73 strain of P. multocida by the palatine cleft method. The degree of efficacy of the various vaccination routes differed among three experiments. Nevertheless, the subcutaneous route produced the greatest degree of protection in all experiments and in two experiments differences were highly significant (P less than .01). Protection levels as high as 95% and 97.5% were attained in broilers vaccinated subcutaneously and no undesirable lesions or cheesy masses formed under the skin in the back of the necks of broilers.
评估了肉用型鸡对多杀性巴氏杆菌克莱姆森大学菌株不同接种途径的免疫反应。在9或10周龄时，通过口服（饮水）、腭裂、眼部或皮下注射途径对肉鸡进行接种。所有鸡在11或12周龄时通过腭裂法用多杀性巴氏杆菌强毒株X-73进行攻毒。不同接种途径的效力程度在三个实验中有所不同。然而，皮下途径在所有实验中提供了最大程度的保护，并且在两个实验中差异极显著（P小于0.01）。皮下接种的肉鸡保护水平高达95%和97.5%，且肉鸡颈部后方皮肤下未形成不良病变或干酪样肿块。
