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盐酸N-2-氰基乙基苯丙胺对大鼠胎盘及某些母体和胎儿组织总脂质含量的影响。

The effect of N-2-cyano-ethylamphetamine. HCl on total lipid contents of placenta and some material and fetal tissues of the rat.

作者信息

Kulay L, Oliveira-Filho R M, Siciliano S F, Kulay M N

出版信息

Rev Bras Pesqui Med Biol. 1978 Dec;11(6):325-8.

PMID:751109
Abstract

Female rats received 1.25 mg/kg body weight of N-2-cyano-ethylamphetamine. HCl (Fenproporex chlorhydrate) by oral route, once daily from the 5th to the 21st day of pregnancy, and compared to untreated pregnant rats, showed an increased total lipid content in maternal blood and fetal hearts; liver and heart have had total lipids decrease, while in placenta and fetal livers they were not observed significant differences.

摘要

雌性大鼠在怀孕第5天至第21天期间,每天经口给予1.25毫克/千克体重的N-2-氰基乙基苯丙胺盐酸盐(芬普雷司盐酸盐)。与未处理的怀孕大鼠相比,给药后的大鼠母体血液和胎儿心脏中的总脂质含量增加;肝脏和心脏的总脂质减少,而胎盘和胎儿肝脏中未观察到显著差异。

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