氯化镉可诱导小鼠骨髓微核频率呈剂量依赖性增加。

Cadmium chloride induces dose-dependent increases in the frequency of micronuclei in mouse bone marrow.

作者信息

Jagetia G C, Adiga S K

机构信息

Department of Radiobiology, Kasturba Medical College, Manipal, Karnataka, India.

出版信息

Mutat Res. 1994 Apr 1;306(1):85-90. doi: 10.1016/0027-5107(94)90170-8.

DOI:10.1016/0027-5107(94)90170-8

PMID:7512206

Abstract

The frequency of micronucleated polychromatic erythrocytes (MPCE) and normochromatic erythrocytes (MNCE) was studied in Swiss albino mice treated with 0, 0.025, 0.05, 0.1, 0.25, 0.5, 1 and 2 mg/kg body weight of cadmium chloride. It was observed that cadmium chloride induced a dose-dependent increase in the frequency of MPCE and MNCE. However, this increase was significant only after treatment with 0.05 mg/kg of CdCl2 (MPCE). The polychromatic and normochromatic erythrocyte ratio (PCE/NCE ratio) declined with the increase in CdCl2 dose and this depletion was dose-dependent. A significant decline was observed only after 0.25 mg/kg CdCl2. The dose-response relationship for all three parameters was linear-quadratic.

摘要

研究了用0、0.025、0.05、0.1、0.25、0.5、1和2mg/kg体重的氯化镉处理的瑞士白化小鼠中微核多色红细胞（MPCE）和正染色红细胞（MNCE）的频率。观察到氯化镉诱导MPCE和MNCE频率呈剂量依赖性增加。然而，仅在用0.05mg/kg的CdCl2处理后（MPCE），这种增加才显著。多色和正染色红细胞比率（PCE/NCE比率）随着CdCl2剂量的增加而下降，并且这种减少是剂量依赖性的。仅在0.25mg/kg CdCl2处理后观察到显著下降。所有三个参数的剂量反应关系均为线性二次关系。