裂变中子和低传能线密度辐射诱发人淋巴细胞微核的剂量-反应关系。

Dose-response relationships of micronuclei in human lymphocytes induced by fission neutrons and by low LET radiations.

作者信息

Huber R, Schraube H, Nahrstedt U, Braselmann H, Bauchinger M

机构信息

Institute of Radiobiology, GSF-Forschungszentrum für Umwelt und Gesundheit, Oberschleissheim, Germany.

出版信息

Mutat Res. 1994 Apr 15;306(2):135-41. doi: 10.1016/0027-5107(94)90024-8.

DOI:10.1016/0027-5107(94)90024-8

PMID:7512212

Abstract

The induction of micronuclei in cytokinesis-blocked human lymphocytes of different donors has been measured after G0 irradiation in vitro with a mixed fission neutron-gamma-ray beam, 220 kV X-rays and 60Co gamma-rays. The dose-response relationships for the micronucleus yields were linear-quadratic for both types of low LET radiations. The linear model applied for neutron-induced micronuclei over the dose range 0-0.66 Gy. At higher doses a saturation effect became apparent. For neutron-induced micronucleus yields a limiting RBE value of 12.2 was derived from the ratio of the alpha coefficients of neutrons and 60Co gamma-rays.

摘要

在体外使用裂变中子-γ射线混合束、220 kV X射线和⁶⁰Co γ射线对处于G0期的不同供体的胞质分裂阻滞人淋巴细胞进行辐照后，测量了微核的诱导情况。对于两种低传能线密度辐射，微核产额的剂量-反应关系均为线性-二次型。在0 - 0.66 Gy剂量范围内，线性模型适用于中子诱导的微核。在更高剂量下，饱和效应变得明显。从中子和⁶⁰Co γ射线的α系数之比得出，中子诱导微核产额的极限相对生物效应值为12.2。