Bing O, Möller C, Engel J A, Söderpalm B, Heilig M
Department of Pharmacology, University of Göteborg, Sweden.
Neurosci Lett. 1993 Dec 24;164(1-2):17-20. doi: 10.1016/0304-3940(93)90846-d.
The neuropeptide galanin is present in limbic brain areas important for emotionality. We examined whether central galanin may be involved in mechanisms of anxiety. Rats were tested in a pharmacologically validated animal model of anxiety, the Vogel punished drinking test. A 100% increase of punished responding was seen after 3 nmol galanin i.c.v. After 15 nmol, signs of sedation were seen, and no increase of punished responding could be observed. Drinking motivation, shock thresholds and exploratory locomotor activity were not affected by 3 nmol galanin. These results support a specific anxiolytic-like action of galanin, similar to that of the functionally related peptide, neuropeptide Y.
神经肽甘丙肽存在于对情绪至关重要的边缘脑区。我们研究了中枢甘丙肽是否可能参与焦虑机制。在一种经过药理学验证的焦虑动物模型——Vogel 惩罚性饮水试验中对大鼠进行了测试。脑室内注射 3 纳摩尔甘丙肽后，惩罚性反应增加了 100%。注射 15 纳摩尔后，出现了镇静迹象，未观察到惩罚性反应增加。3 纳摩尔甘丙肽对饮水动机、电击阈值和探索性运动活动没有影响。这些结果支持甘丙肽具有特定的抗焦虑样作用，类似于功能相关肽神经肽 Y 的作用。
