Maurelli M, Marchioni E, Tartara A
Istituto Neurologico C. Mondino, Università di Pavia.
Boll Soc Ital Biol Sper. 1993 Jul-Aug;69(7-8):485-91.
The effects of centrally administered galanin (10 and 20 mcg) on the EEG, somatic behaviour and some autonomic parameters have been studied in unanesthetized rabbits. In this species the peptide induced a dose related increase in electrocortical power spectrum density and behavioural sedation. Autonomic changes, consisting in moderate hyperthermia and bradypnea, were seen only after the highest dose of the peptide. These data support a central action of the peptide and suggest a role for galanin as sedative neuropeptide.
已经在未麻醉的兔子身上研究了中枢给予甘丙肽（10微克和20微克）对脑电图、躯体行为和一些自主神经参数的影响。在该物种中，这种肽引起了与剂量相关的皮质电图功率谱密度增加和行为镇静。仅在给予最高剂量的肽后才观察到自主神经变化，包括中度体温过高和呼吸过缓。这些数据支持了该肽的中枢作用，并表明甘丙肽作为一种镇静性神经肽发挥作用。
