Hansson L
Department of Geriatrics, University of Uppsala, Sweden.
Drugs. 1993;46 Suppl 2:37-9. doi: 10.2165/00003495-199300462-00008.
Numerous intervention studies have clearly demonstrated the value of antihypertensive treatment. By lowering diastolic blood pressure 5 to 6mm Hg in middle-aged hypertensive patients, a 42% reduction in stroke morbidity and a 14% reduction in coronary heart disease morbidity can be obtained. Recently published large intervention trials have shown that antihypertensive treatment provides even greater benefits in elderly hypertensive patients. Not only are cardiovascular morbidity and mortality reduced, but, in the 'old elderly', total mortality is reduced when blood pressure is lowered. It is conceivable that even better outcomes will be achieved with newer antihypertensive therapies, such as calcium antagonists and angiotensin converting enzyme inhibitors, and this possibility is being investigated in large prospective intervention trials.
众多干预研究已清楚地证明了抗高血压治疗的价值。通过将中年高血压患者的舒张压降低5至6毫米汞柱，可使中风发病率降低42%，冠心病发病率降低14%。最近发表的大型干预试验表明，抗高血压治疗在老年高血压患者中能带来更大益处。不仅心血管发病率和死亡率降低，而且在“高龄老人”中，血压降低时总死亡率也会降低。可以想象，使用钙拮抗剂和血管紧张素转换酶抑制剂等新型抗高血压疗法将取得更好的效果，目前正在大型前瞻性干预试验中对此可能性进行研究。
