Kalish J, Cooner W H, Graham S D
Department of Surgery, Emory University School of Medicine, Atlanta, Georgia.
Urology. 1994 May;43(5):601-6. doi: 10.1016/0090-4295(94)90170-8.
This study evaluates the accuracy of comparing serum prostate-specific (PSA) levels in the range between 4.1 ng/mL and 10.0 ng/mL (monoclonal) to the volume of the transition zone (TZ) of the prostate and total gland volume as a predictor of a positive biopsy.
Using sonographic voluming of the entire prostate and of the TZ, prostate-specific antigen density (PSAD) and prostate-specific antigen density of the TZ (PSAT) were calculated in 21 biopsy-positive patients and 38 biopsy-negative patients. Biopsy was directed at sonographically suspicious areas and did not include sextant biopsies.
A statistically significant association was determined between a positive biopsy and gland volume, TZ volume, and PSAT. The association of a positive biopsy with PSA and PSAD was not statistically significant.
PSAT is more accurate in predicting a positive biopsy than is PSAD for PSA levels between 4.1 ng/mL and 10.0 ng/mL.
本研究评估在4.1纳克/毫升至10.0纳克/毫升（单克隆）范围内比较血清前列腺特异性抗原（PSA）水平与前列腺移行区（TZ）体积及全腺体积作为阳性活检预测指标的准确性。
对21例活检阳性患者和38例活检阴性患者，通过超声测量整个前列腺及TZ的体积，计算前列腺特异性抗原密度（PSAD）和TZ的前列腺特异性抗原密度（PSAT）。活检针对超声可疑区域，不包括六分区活检。
确定活检阳性与腺体体积、TZ体积及PSAT之间存在统计学显著关联。活检阳性与PSA和PSAD之间的关联无统计学意义。
对于4.1纳克/毫升至10.0纳克/毫升的PSA水平，PSAT在预测阳性活检方面比PSAD更准确。
