Savage J R, Simpson P
MRC Radiobiology Unit, Chilton, Didcot, UK.
Mutat Res. 1994 May 1;307(1):345-53. doi: 10.1016/0027-5107(94)90308-5.
The effectiveness of FISH painting for easy detection of radiation-induced chromosome aberrations lies, principally, in the fact that only part of any exchange event is highlighted. However, this partial detection imposes certain limitations when the technique is applied to fundamental studies with primary aberrations, particularly at higher doses, when Complex exchanges are present. Some of these limitations are discussed in this paper.
荧光原位杂交（FISH）技术用于轻松检测辐射诱导的染色体畸变，其有效性主要在于任何交换事件中只有一部分会被突出显示。然而，当该技术应用于原发性畸变的基础研究时，这种部分检测会带来一定的局限性，特别是在存在复杂交换且剂量较高的情况下。本文将讨论其中的一些局限性。
