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在健康个体和癌症患者中，具有明显放射性敏感性增加的个体比例均随年龄增长而升高。

Rate of individuals with clearly increased radiosensitivity rise with age both in healthy individuals and in cancer patients.

机构信息

Department of Radiation Oncology, University Hospital Erlangen Friedrich-Alexander-Universität Erlangen-Nürnberg, Universitätsstr. 27, 91054, Erlangen, Germany.

Department of Radiology, Charité Universitätsmedizin, Berlin, Germany.

出版信息

BMC Geriatr. 2018 May 4;18(1):105. doi: 10.1186/s12877-018-0799-y.

DOI:10.1186/s12877-018-0799-y
PMID:29728069
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5935967/
Abstract

BACKGROUND

The question of an age dependence of individual radiosensitivity has only marginally been studied so far. Therefore, we analyzed blood samples of healthy individuals and cancer patients of different ages to determine individual radiosensitivity.

METHODS

Ex vivo irradiated blood samples of 595 individuals were tested. Chromosomes 1, 2 and 4 were stained by 3-color fluorescence in situ hybridization and aberrations were analyzed. Radiosensitivity was determined by the mean breaks per metaphase (B/M).

RESULTS

Healthy individuals (mean age 50.7 years) had an average B/M value of 0.42 ± 0.104 and an increase of 0.0014B/M per year. The patients (mean age 60.4 years) had an average B/M value of 0.44 ± 0.150 and radiosensitivity did not change with age. In previous studies we found that from a value of 0.6B/M on an individual is considered to be distinctly radiosensitive. The portion of radiosensitive individuals (B/M > 0.6) increased in both cohorts with age.

CONCLUSION

Individual radiosensitivity rises continuously with age, yet with strong interindividual variation. No age related increase of radiosensitivity can be demonstrated in patients due to the strong interindividual variation. However among old cancer patients there is a higher probability to have patients with clearly increased radiosensitivity than at younger age.

摘要

背景

目前为止，个体放射性敏感度的年龄依赖性问题仅得到了有限的研究。因此，我们分析了不同年龄的健康个体和癌症患者的血液样本，以确定个体放射性敏感度。

方法

对 595 个人的离体辐照血液样本进行了测试。通过三色荧光原位杂交对染色体 1、2 和 4 进行染色，并分析了染色体畸变。通过中期分裂的平均断裂数（B/M）来确定放射性敏感度。

结果

健康个体（平均年龄 50.7 岁）的平均 B/M 值为 0.42±0.104，每年增加 0.0014B/M。患者（平均年龄 60.4 岁）的平均 B/M 值为 0.44±0.150，且放射性敏感度不随年龄变化。在之前的研究中，我们发现个体的 B/M 值超过 0.6 时被认为具有明显的放射性敏感度。两个队列中，随着年龄的增长，放射性敏感度较高的个体（B/M>0.6）的比例均有所增加。

结论

个体放射性敏感度随年龄不断上升，但个体间差异较大。由于个体间差异较大，患者的放射性敏感度没有随年龄增加的趋势。然而，在老年癌症患者中，与年轻患者相比，具有明显增加的放射性敏感度的患者的概率更高。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a92/5935967/4ea75958bac4/12877_2018_799_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a92/5935967/af739f84ca09/12877_2018_799_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a92/5935967/b219d8b6c984/12877_2018_799_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a92/5935967/4ea75958bac4/12877_2018_799_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a92/5935967/af739f84ca09/12877_2018_799_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a92/5935967/b219d8b6c984/12877_2018_799_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a92/5935967/4ea75958bac4/12877_2018_799_Fig3_HTML.jpg

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