Lifschitz-Mercer B, Open M, Kushnir I, Czernobilsky B
Department of Pathology, Kaplan Hospital, Jerusalem, Israel.
Virchows Arch. 1994;424(2):213-6. doi: 10.1007/BF00193502.
The stratified squamous epithelium of a splenic epidermoid cyst was studied with a battery of monoclonal antibodies to cytokeratin (CK) proteins. CKs 10 and 11 were found in the suprabasal layers of the stratified squamous epithelium, while staining for CK 13 was focal or diffuse throughout. CKs 18 and 19 decorated individual squamous cells or stained the entire thickness of the epithelium. These results were compared with those previously obtained by us in stratified squamous epithelia of ovarian mature cystic teratoma, fetal epidermis, adult epidermis and squamous metaplasia in a peritoneal cyst. From these comparisons it emerges that the epidermoid splenic cyst is either of teratomatous derivation or originates from inclusion of fetal squamous epithelium. Squamous metaplasia of mesothelium or inclusions of mature squamous epithelium appears to be an unlikely source of origin of these cysts.
运用一系列针对细胞角蛋白（CK）蛋白的单克隆抗体，对脾脏表皮样囊肿的复层鳞状上皮进行了研究。在复层鳞状上皮的基底层上方发现了CK10和CK11，而CK13的染色则呈局灶性或弥漫性分布于整个上皮。CK18和CK19标记单个鳞状细胞或染遍上皮全层。将这些结果与我们之前在卵巢成熟囊性畸胎瘤、胎儿表皮、成人表皮以及腹膜囊肿中的鳞状化生的复层鳞状上皮中所获得的结果进行了比较。通过这些比较发现，脾脏表皮样囊肿要么来源于畸胎瘤，要么起源于胎儿鳞状上皮的包埋。间皮的鳞状化生或成熟鳞状上皮的包埋似乎不太可能是这些囊肿的起源。
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