H-2Ld分子中的单个Dd氨基酸取代可识别抗体表位。 - Suppr

Suppr

超能文献

Single Dd amino acid substitutions in the H-2Ld molecule identify antibody epitopes.

作者信息

McKinney D M, Chen P, McMillan M

机构信息

Department of Microbiology, University of Southern California School of Medicine, Los Angeles 90033.

出版信息

Immunogenetics. 1994;39(6):440-3. doi: 10.1007/BF00176164.

DOI:10.1007/BF00176164

PMID:7514573

Abstract

摘要

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Single Dd amino acid substitutions in the H-2Ld molecule identify antibody epitopes.H-2Ld分子中的单个Dd氨基酸取代可识别抗体表位。

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An immunodominant epitope present in multiple class I MHC molecules and recognized by cytotoxic T lymphocytes.一种存在于多种I类主要组织相容性复合体分子中并被细胞毒性T淋巴细胞识别的免疫显性表位。

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Cytotoxic T lymphocytes recognize determinants on the BALB/c-H-2Ld molecule controlled by alpha 1 and alpha 2 but not alpha 3 external domains.细胞毒性T淋巴细胞识别由α1和α2而非α3外部结构域控制的BALB/c - H - 2Ld分子上的决定簇。

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The role of L3T4 in recognition of Ia by a cytotoxic, H-2Dd-specific T cell hybridoma.L3T4在一种细胞毒性、H-2Dd特异性T细胞杂交瘤识别Ia中的作用。

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Mutations inside but not outside the peptide binding cleft of the H-2 Ld molecule affect CTL recognition and binding of the nucleoprotein peptide from the lymphocytic choriomeningitis virus.H-2 Ld分子肽结合裂隙内部而非外部的突变会影响细胞毒性T淋巴细胞（CTL）对淋巴细胞性脉络丛脑膜炎病毒核蛋白肽的识别和结合。

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本文引用的文献

Alloantibodies can discriminate class I major histocompatibility complex molecules associated with various endogenous peptides.同种异体抗体能够区分与各种内源性肽相关的I类主要组织相容性复合体分子。

Proc Natl Acad Sci U S A. 1993 Aug 1;90(15):6949-51. doi: 10.1073/pnas.90.15.6949.

Binding of peptides lacking consensus anchor residue alters H-2Ld serologic recognition.缺乏共有锚定残基的肽的结合改变了H-2Ld血清学识别。

J Immunol. 1993 Nov 15;151(10):5387-97.

Amino acid changes in the peptide binding site have structural consequences at the surface of class I glycoproteins.肽结合位点中的氨基酸变化在I类糖蛋白表面产生结构后果。

J Immunol. 1993 Apr 15;150(8 Pt 1):3375-81.

Monoclonal antibodies to mouse MHC antigens. II. Antibodies to the H-2Ld antigen, the products of a third polymorphic locus of the mouse major histocompatibility complex.针对小鼠MHC抗原的单克隆抗体。II. 针对H-2Ld抗原的抗体，小鼠主要组织相容性复合体第三个多态性位点的产物

J Immunol. 1980 Dec;125(6):2473-7.

Exon shuffling: mapping polymorphic determinants on hybrid mouse transplantation antigens.外显子改组：在杂种小鼠移植抗原上定位多态性决定簇

Nature. 1982 Dec 23;300(5894):755-7. doi: 10.1038/300755a0.

Analysis of the D-region products of H-2q using monoclonal antibodies reveals the expression of a new class I-like molecule.使用单克隆抗体对H-2q的D区产物进行分析，揭示了一种新的I类样分子的表达。

Immunogenetics. 1987;25(1):7-14. doi: 10.1007/BF00768827.

Amino acid comparison of the class I antigens of mouse major histocompatibility complex.小鼠主要组织相容性复合体I类抗原的氨基酸比较

Immunogenetics. 1989;30(5):390-2. doi: 10.1007/BF02425281.

J Immunol. 1985 Mar;134(3):1749-58.

Introduction of H-2Dd determinants into the H-2Ld antigen by site-directed mutagenesis.通过定点诱变将H-2Dd决定簇引入H-2Ld抗原。

J Exp Med. 1987 Sep 1;166(3):744-60. doi: 10.1084/jem.166.3.744.

Fine mapping of epitopes by intradomain Kd/Dd recombinants.通过结构域内Kd/Dd重组体进行表位的精细定位。

J Exp Med. 1987 Aug 1;166(2):327-40. doi: 10.1084/jem.166.2.327.

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