Rudolph R, Dölling J, Kunkel G, Staud R D, Baumgarten C
Allergy. 1978 Dec;33(6):310-5. doi: 10.1111/j.1398-9995.1978.tb01556.x.
In 57 patients with house dust allergy and 20 controls protease inhibitor concentrations in nasal secretions were measured before and after antigen challenge. A correlation was found between low inhibitor levels and long duration of disease. Furthermore, significant differences of inhibitor concentrations could be demonstrated between patients with strong or moderate reactions to antigen provocation, and between patients with isolated rhinitis or a combination of rhinitis and bronchial asthma. The clinical significance of the results will be discussed with special regard to different biochemical mechanisms in the pathophysiology of seasonal and perennial immediate-type rhinitis.
对57例屋尘过敏患者和20例对照者在抗原激发前后测定鼻分泌物中的蛋白酶抑制剂浓度。发现抑制剂水平低与病程长之间存在相关性。此外，在对抗原激发有强烈或中度反应的患者之间，以及在单纯性鼻炎患者或鼻炎合并支气管哮喘患者之间，可证明抑制剂浓度存在显著差异。将结合季节性和常年性速发型鼻炎病理生理学中不同的生化机制来讨论这些结果的临床意义。
