血红素结合蛋白基因座：其在实验用兔（穴兔）中与连锁群I的定位及第四个等位基因的证据。

The hemopexin locus: its assignment to linkage group I in the laboratory rabbit (Oryctolagus cuniculus) and evidence for a fourth allele.

作者信息

Hagen K L, Suzuki Y, Tissot R, Cohen C

出版信息

Anim Blood Groups Biochem Genet. 1978;9(3):151-9. doi: 10.1111/j.1365-2052.1978.tb01428.x.

DOI:10.1111/j.1365-2052.1978.tb01428.x

Abstract

The hemopexin locus phenotypes were determined for 450 animals with polyacrylamide gel electrophoresis, and the presence of a fourth allele at this locus was revealed. Of the 19 mating types segregating at this locus, 17 demonstrated segregation ratios consistent with the hypothesis of a four allele, codominant, autosomal system. Studies of three of our largest inbreeding lines indicated that fixation at this locus has occurred in two of them. Linkage studies showed that the Hx locus is located between the color locus, c, and the Hq blood group locus; therefore it is assigned to Linkage Group I of the rabbit.

摘要

采用聚丙烯酰胺凝胶电泳法测定了450只动物的血红素结合蛋白基因座表型，结果显示该基因座存在第四个等位基因。在该基因座分离的19种交配类型中，有17种的分离比例符合四等位基因、共显性、常染色体系统的假说。对我们三个最大的近交系的研究表明，其中两个系在该基因座已发生固定。连锁研究表明，Hx基因座位于毛色基因座c和Hq血型基因座之间；因此，它被归入兔的连锁群I。