Chorvatovicová D
Institute of Experimental Pharmacology, Slovak Academy of Sciences, Bratislava.
Mutat Res. 1994 Jun;324(1-2):7-11. doi: 10.1016/0165-7992(94)90060-4.
Induction of micronuclei was studied 40 h post irradiation in peripheral blood reticulocytes of male mice treated or not with stobadine dipalmitate (70.07 mg/kg body weight) at two time intervals (2 h or 1 h) prior to and immediately after 6.5 Gy 60Co exposure. A significant decrease of micronucleated reticulocytes was observed in the group of mice pretreated 2 h (P < 0.05) or 1 h (P < 0.01) before irradiation. 60Co irradiation followed by treatment with stobadine did not lead to the same protective effect in the micronucleus assay. It is therefore assumed that a radical-scavenging mechanism must be involved in radioprotection by stobadine.
在6.5 Gy 60Co照射之前和之后立即的两个时间间隔（2小时或1小时），对用或不用二棕榈酸司他丁（70.07 mg/kg体重）处理的雄性小鼠外周血网织红细胞在照射后40小时进行微核诱导研究。在照射前2小时（P < 0.05）或1小时（P < 0.01）预处理的小鼠组中，观察到微核网织红细胞显著减少。60Co照射后用司他丁处理在微核试验中未产生相同的保护作用。因此推测司他丁的辐射防护作用必定涉及自由基清除机制。
