Stefek M, Trnkova Z
Institute of Experimental Pharmacology, Slovak Academy of Sciences, Bratislava, Slovak Republic.
Pharmacol Toxicol. 1995 Nov;77(5):320-2. doi: 10.1111/j.1600-0773.1995.tb01034.x.
Alloxan-induced hyperglycaemia was used as a model of free radical pathology to test the antioxidant activity of the pyridoindole drug, stobadine, in the intact mouse. Stobadine was injected intraperitoneally in a dose range 7.5-60 mg/kg prior to intravenous injection of alloxan (50 mg/kg), and blood glucose concentration 72 hr after alloxan administration was used as an index of alloxan toxicity. Stobadine efficiently suppressed the alloxan-induced hyperglycaemia in a dose-dependent manner. This protection against the diabetogenic effect of alloxan is consistent with the high efficacy of stobadine to scavenge hydroxyl radicals.
用四氧嘧啶诱导的高血糖症作为自由基病理模型，以测试吡啶并吲哚药物司他定在完整小鼠体内的抗氧化活性。在静脉注射四氧嘧啶（50mg/kg）之前，以7.5-60mg/kg的剂量范围腹腔注射司他定，将四氧嘧啶给药72小时后的血糖浓度用作四氧嘧啶毒性的指标。司他定以剂量依赖的方式有效抑制四氧嘧啶诱导的高血糖症。这种对四氧嘧啶致糖尿病作用的保护作用与司他定清除羟基自由基的高效性一致。
