Furuno T, Hara N, Hagimoto N, Mori N, Muranishi H
Research Institute for the Diseases of the Chest, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Chest. 1994 Jun;105(6):1893-5. doi: 10.1378/chest.105.6.1893.
An 18-year-old man was admitted to our hospital with high temperature and dyspnea. A chest radiograph revealed the presence of multiple round nodules compatible with a metastatic lung cancer. The peripheral white blood cell count was 22,000/mm3 and more than 85 percent were atypical large lymphocytes with azurophilic granules. He was diagnosed as having natural killer (NK)-cell granular lymphocyte proliferative disorder (NK-GLPD) as the lymphocytes were positive with CD56, a cell surface marker characteristic for NK cells. The major pathologic finding of the tissue collected from the pulmonary nodules by transbronchial lung biopsy was infiltration of mostly large granular lymphocytes.
一名18岁男性因高热和呼吸困难入院。胸部X线片显示有多个圆形结节，符合转移性肺癌表现。外周血白细胞计数为22,000/mm³，超过85%为有嗜苯胺蓝颗粒的非典型大淋巴细胞。由于淋巴细胞CD56呈阳性（CD56是NK细胞特征性的细胞表面标志物），他被诊断为自然杀伤（NK）细胞颗粒淋巴细胞增殖性疾病（NK - GLPD）。经支气管肺活检从肺结节采集的组织的主要病理发现是主要为大颗粒淋巴细胞浸润。
