Burrows T D, King A, Loke Y W
Department of Pathology, University of Cambridge, UK.
Placenta. 1994 Jan;15(1):21-33. doi: 10.1016/s0143-4004(05)80233-4.
During the process of implantation, maternal spiral arteries within the decidua are invaded by trophoblast cells that adhere to and migrate along the luminal surface of the vascular endothelial cells. This phenomenon resembles the events that occur during the migration of neutrophils into an acute inflammatory site, therefore it is possible that similar mechanisms are involved. Indeed, previous observations have shown that endovascular trophoblast expresses the blood group-related antigen sialyl Le(x). In this study, we show, by immunohistology, the expression of both E- and P-selectin by vascular endothelial cells only in the decidua basalis and not in decidua parietalis. In contrast, ICAM-1 is expressed by all vascular endothelium throughout the decidua. Expression of VCAM-1 is variable at the implantation site, and is not expressed by vascular endothelial cells in decidua parietalis. Interestingly, we demonstrate the strong expression of a polysialylated form of NCAM by endovascular trophoblast. Our data suggests that vascular invasion by trophoblast is regulated by the expression of appropriate adhesion molecules which permit interaction between endovascular trophoblast and decidual endothelial cells.
在着床过程中，蜕膜内的母体螺旋动脉被滋养层细胞侵入，这些细胞附着于血管内皮细胞的管腔表面并沿其迁移。这种现象类似于中性粒细胞迁移到急性炎症部位时发生的事件，因此可能涉及类似的机制。事实上，先前的观察表明，血管内滋养层表达血型相关抗原唾液酸化刘易斯x（sialyl Le(x)）。在本研究中，我们通过免疫组织学显示，仅在基蜕膜而非壁蜕膜的血管内皮细胞中表达E-选择素和P-选择素。相比之下，整个蜕膜中的所有血管内皮均表达细胞间黏附分子-1（ICAM-1）。血管细胞黏附分子-1（VCAM-1）在着床部位的表达是可变的，壁蜕膜中的血管内皮细胞不表达。有趣的是，我们证明血管内滋养层强烈表达多唾液酸化形式的神经细胞黏附分子（NCAM）。我们的数据表明，滋养层的血管侵入受适当黏附分子表达的调节，这些黏附分子允许血管内滋养层与蜕膜内皮细胞之间相互作用。
