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胎-胎盘单位:从发育到功能。

Feto-placental Unit: From Development to Function.

机构信息

Health Sciences Faculty, Universidad San Sebastián, Concepción, Chile.

Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

出版信息

Adv Exp Med Biol. 2023;1428:1-29. doi: 10.1007/978-3-031-32554-0_1.

DOI:10.1007/978-3-031-32554-0_1
PMID:37466767
Abstract

The placenta is an intriguing organ that allows us to survive intrauterine life. This essential organ connects both mother and fetus and plays a crucial role in maternal and fetal well-being. This chapter presents an overview of the morphological and functional aspects of human placental development. First, we describe early human placental development and the characterization of the cell types found in the human placenta. Second, the human placenta from the second trimester to the term of gestation is reviewed, focusing on the morphology and specific pathologies that affect the placenta. Finally, we focus on the placenta's primary functions, such as oxygen and nutrient transport, and their importance for placental development.

摘要

胎盘是一种有趣的器官,它使我们能够在子宫内生存。这个重要的器官连接着母亲和胎儿,在母婴健康中起着至关重要的作用。本章介绍了人类胎盘发育的形态和功能方面的概述。首先,我们描述了早期人类胎盘的发育以及在人类胎盘内发现的细胞类型的特征。其次,我们回顾了从妊娠中期到足月的人类胎盘,重点介绍了影响胎盘的形态和特定病变。最后,我们专注于胎盘的主要功能,如氧气和营养物质的运输,以及它们对胎盘发育的重要性。

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1
Feto-placental Unit: From Development to Function.胎-胎盘单位:从发育到功能。
Adv Exp Med Biol. 2023;1428:1-29. doi: 10.1007/978-3-031-32554-0_1.
2
Maternal dietary fatty acids and their roles in human placental development.母体膳食脂肪酸及其在人类胎盘发育中的作用。
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4
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Cells. 2023 Mar 3;12(5):797. doi: 10.3390/cells12050797.
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Impact of Ionizing Radiation Exposure on Placental Function and Implications for Fetal Programming.电离辐射暴露对胎盘功能的影响及其对胎儿编程的影响。
Int J Mol Sci. 2024 Sep 12;25(18):9862. doi: 10.3390/ijms25189862.
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Brief hyperglycaemia in the early pregnant rat increases fetal weight at term by stimulating placental growth and affecting placental nutrient transport.妊娠早期大鼠的短暂高血糖通过刺激胎盘生长和影响胎盘营养物质转运,增加足月时胎儿体重。
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Pathophysiology of intrauterine growth retardation: role of the placenta.宫内生长受限的病理生理学:胎盘的作用
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Review: Nutrient sulfate supply from mother to fetus: Placental adaptive responses during human and animal gestation.综述:从母体到胎儿的营养性硫酸盐供应:人类和动物妊娠期胎盘的适应性反应。
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Identification and characterization of signature genes related to fetoplacental vascular endothelial cell programming in gestational diabetes mellitus using bioinformatics analysis.运用生物信息学分析鉴定和表征妊娠期糖尿病中与胎儿胎盘血管内皮细胞编程相关的特征基因
Front Genet. 2025 Jul 14;16:1600756. doi: 10.3389/fgene.2025.1600756. eCollection 2025.
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The role of DNA methylation in placental development and its implications for preeclampsia.DNA甲基化在胎盘发育中的作用及其对子痫前期的影响。
Front Cell Dev Biol. 2024 Dec 3;12:1494072. doi: 10.3389/fcell.2024.1494072. eCollection 2024.
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Diagnosis, Prevention, and Management of Fetal Growth Restriction (FGR).

本文引用的文献

1
Association between levels of aquaporin 3 in the placenta and adiponectin in the umbilical cord blood with gestational diabetes mellitus and pregnancy outcome.胎盘水通道蛋白 3 水平与脐血脂联素与妊娠期糖尿病及妊娠结局的关系。
Mol Med Rep. 2020 Aug;22(2):1498-1506. doi: 10.3892/mmr.2020.11225. Epub 2020 Jun 12.
2
First trimester placental volume and vascular indices in pregestational diabetic compared to nondiabetic pregnant women.与非糖尿病孕妇相比,妊娠糖尿病孕妇孕早期胎盘体积和血管指数的情况。
J Obstet Gynaecol Res. 2020 Aug;46(8):1326-1332. doi: 10.1111/jog.14271. Epub 2020 Jun 25.
3
The haemodynamics of the human placenta in utero.
胎儿生长受限(FGR)的诊断、预防与管理
J Pers Med. 2024 Jun 28;14(7):698. doi: 10.3390/jpm14070698.
4
Exploring maternal-fetal interface with in vitro placental and trophoblastic models.利用体外胎盘和滋养层模型探索母胎界面
Front Cell Dev Biol. 2023 Nov 14;11:1279227. doi: 10.3389/fcell.2023.1279227. eCollection 2023.
人体胎盘在子宫内的血液动力学。
PLoS Biol. 2020 May 28;18(5):e3000676. doi: 10.1371/journal.pbio.3000676. eCollection 2020 May.
4
Early sonographic evaluation of the placenta in cases with IUGR: a pilot study.胎儿生长受限病例中胎盘的早期超声评估:一项初步研究。
Arch Gynecol Obstet. 2020 Aug;302(2):337-343. doi: 10.1007/s00404-020-05601-7. Epub 2020 May 25.
5
Materno-fetal cholesterol transport during pregnancy.妊娠期间母胎胆固醇转运。
Biochem Soc Trans. 2020 Jun 30;48(3):775-786. doi: 10.1042/BST20190129.
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Fetal Gestational Age Determination using Ultrasound Placental Thickness.利用超声胎盘厚度测定胎儿孕周
J Med Ultrasound. 2019 Oct 9;28(1):17-23. doi: 10.4103/JMU.JMU_127_18. eCollection 2020 Jan-Mar.
7
Cholesterol uptake and efflux are impaired in human trophoblast cells from pregnancies with maternal supraphysiological hypercholesterolemia.胆固醇摄取和外排功能受损在患有母体高胆固醇血症的人类滋养层细胞中。
Sci Rep. 2020 Mar 24;10(1):5264. doi: 10.1038/s41598-020-61629-4.
8
Placenta accreta spectrum: biomarker discovery using plasma proteomics.胎盘植入谱系疾病:血浆蛋白质组学的生物标志物发现。
Am J Obstet Gynecol. 2020 Sep;223(3):433.e1-433.e14. doi: 10.1016/j.ajog.2020.03.019. Epub 2020 Mar 19.
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A Literature Review of Placenta Accreta Spectrum Disorder: The Place of Expectant Management in Ethiopian Setup.胎盘植入谱系障碍的文献综述:埃塞俄比亚背景下期待疗法的地位
Ethiop J Health Sci. 2020 Mar;30(2):277-292. doi: 10.4314/ejhs.v30i2.16.
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Ultrasound evaluation of a bilobed placenta with 'battledore cord insertion' - a report of an unusual case.超声评估双叶胎盘伴“球拍状脐带插入”——1例罕见病例报告
Ginekol Pol. 2020;91(2):100. doi: 10.5603/GP.2020.0022.