Le Bourgeois J P, Frikha H, Piedbois P, Le Péchoux C, Martin L, Haddad E
Département de cancérologie, Hôpital Henri Mondor, Creteil, France.
Radiother Oncol. 1994 Mar;30(3):263-6. doi: 10.1016/0167-8140(94)90467-7.
From January 1987 to December 1992, 420 patients with acquired immunodeficiency syndrome (AIDS)-related epidemic Kaposi's sarcoma (EKS) were treated with radiotherapy at the oncology department in the Henri Mondor Hospital. Of these, 146 (34.7%) exhibited tumours at 186 sites; 35 were oral, 102 eyelid or conjunctival (ophthalmic), and 49 penile or scrotal (genital) sites. Most patients had received prior chemotherapy. Radiation therapy consisted of 4 MV or 45 kV X-rays, depending on tumor size and location. Doses ranged from 10 to 30 Gy, according to tumor response and toxicity. In oral lesions mucosal reactions were often observed after relatively low doses of radiotherapy. In 27 patients receiving 15 Gy, severe reactions were observed in 6 (22%), moderate reactions in 4 (15%) and mild reactions in 17 (63%). By contrast, irradiation of eyelid or conjunctival lesions and genital lesions, was well-tolerated. Treatment was generally successful in achieving good symptom palliation. Eyelid and conjunctival Kaposi's sarcoma seemed to be more radiosensitive when compared with cutaneous sites: a high objective remission rate (96%, 98/102) was observed at doses ranging from 10 to 20 Gy. Penile and scrotal lesions showed a good response to low dose radiation (complete response was scored in 34/49 patients (69.4%)). A meticulous evaluation of tolerance was necessary. Toxicity of oropharyngeal irradiation at relatively low doses is an argument for a restrictive use of this procedure in oral lesions.
1987年1月至1992年12月，420例患有获得性免疫缺陷综合征（AIDS）相关的流行性卡波西肉瘤（EKS）的患者在亨利·蒙多医院肿瘤科接受了放射治疗。其中，146例（34.7%）在186个部位出现肿瘤；35个为口腔部位，102个为眼睑或结膜（眼部）部位，49个为阴茎或阴囊（生殖器）部位。大多数患者此前接受过化疗。放射治疗采用4兆伏或45千伏的X射线，具体取决于肿瘤大小和位置。根据肿瘤反应和毒性，剂量范围为10至30戈瑞。在口腔病变中，相对低剂量的放射治疗后常观察到黏膜反应。在27例接受15戈瑞治疗的患者中，6例（22%）出现严重反应，4例（15%）出现中度反应，17例（63%）出现轻度反应。相比之下，眼睑或结膜病变以及生殖器病变的放射治疗耐受性良好。治疗在实现良好的症状缓解方面总体上是成功的。与皮肤部位相比，眼睑和结膜卡波西肉瘤似乎对放射更敏感：在10至20戈瑞的剂量范围内观察到较高的客观缓解率（96%，98/102）。阴茎和阴囊病变对低剂量放射显示出良好反应（34/49例患者（69.4%）达到完全缓解）。必须对耐受性进行细致评估。相对低剂量的口咽放射治疗的毒性是在口腔病变中限制使用该程序的一个理由。
