Okuno H, Xie Z C, Lu B Y, Qin X, Fukushima S, Hirota T, Shiozaki Y, Inoue K
Third Department of Internal Medicine, Kansai Medical University, Osaka, Japan.
J Gastroenterol Hepatol. 1994 Mar-Apr;9(2):169-71. doi: 10.1111/j.1440-1746.1994.tb01238.x.
Hepatitis C virus (HCV) has been subdivided into at least four genotypes, and the prevalence of each genotype has been reported to differ widely in different countries. Of 304 patients with chronic liver diseases (68 with chronic hepatitis, 50 with liver cirrhosis and 186 with hepatocellular carcinoma) from Guangxi Province in southern China, only 9 (3.0%) had antibodies to HCV as determined by a second-generation enzyme immunoassay with a cut-off index of 2.0 or more. The HCV genotypes of these nine cases were examined using polymerase chain reaction with type-specific primers deduced from putative core gene. Seven of the nine cases had type II infection and the other two cases showed double infection with types II and IV. These findings indicate that the predominant HCV genotype in the Guangxi area is type II, as is the case in Japan, although the prevalence of HCV infection in patients with chronic liver diseases is much lower.
丙型肝炎病毒（HCV）已被细分为至少四种基因型，据报道，每种基因型在不同国家的流行率差异很大。在中国南方广西省的304例慢性肝病患者（68例慢性肝炎、50例肝硬化和186例肝细胞癌）中，采用第二代酶免疫测定法（临界指数为2.0或更高）检测，只有9例（3.0%）抗HCV抗体呈阳性。使用从推定核心基因推导的型特异性引物通过聚合酶链反应检测这9例患者的HCV基因型。9例中有7例为II型感染，另外2例为II型和IV型双重感染。这些发现表明，广西地区主要的HCV基因型为II型，与日本的情况相同，尽管慢性肝病患者中HCV感染的流行率要低得多。
