Lazarev V V, Poliaev Iu A, Vodolazov Iu A, Nikanorov A Iu
Vestn Ross Akad Med Nauk. 1994(3):47-50.
The nonionic radioopaque ultravist and the high-molar radioopaque verograffin were studied for their effects on the blood osmotic status of children with lower renal concentrating function. A total of 36 children aged 8 months to 12 years who had pyelonephritis, hydronephrosis and renal injury at their acute stage were studied angiographically under general anesthesia. The radioopaque was injected in a mean dose of 2 ml/kg for 2-3 sec. Ultravist was found to have a less osmotic action on the blood osmotic status than did verograffin. The changes in the detectable major blood osmotic parameters: sodium, potassium, glucose, urea, creatine were less pronounced. Plasma osmolality was moderately increased with ultravist and much higher than its normal values with verograffin at min 1 after its administration and at hour 2 of the study. Ultravist is preferable as a radiopaque used in children with decreased renal concentrating function.
对非离子型不透射线的优维显和高摩尔浓度不透射线的泛影葡胺进行了研究，观察它们对肾浓缩功能较低儿童血液渗透压状态的影响。总共36名年龄在8个月至12岁之间、处于急性肾盂肾炎、肾积水和肾损伤阶段的儿童在全身麻醉下接受血管造影研究。不透射线剂以平均2 ml/kg的剂量在2 - 3秒内注入。发现优维显对血液渗透压状态的渗透作用比泛影葡胺小。可检测的主要血液渗透压参数（钠、钾、葡萄糖、尿素、肌酐）的变化不太明显。使用优维显时血浆渗透压适度升高，而使用泛影葡胺后1分钟及研究2小时时血浆渗透压远高于其正常值。对于肾浓缩功能降低的儿童，优维显作为不透射线剂更可取。
