胆碱缺乏时影响脂蛋白脂肪酶活性的因素。

Factors influencing lipoprotein lipase activity in choline deficiency.

作者信息

Waller A R, Kratzing C C

出版信息

Aust J Exp Biol Med Sci. 1978 Oct;56(5):617-22. doi: 10.1038/icb.1978.69.

DOI:10.1038/icb.1978.69

Abstract

Subcutaneous injections of the lipotropic agent, ethyl trichloracetate, to rats with established choline deficiency raised their plasma triglycerides by 60% and completely removed the hyperglyceridaemic response of Triton WR 1339. The plasma triglyceride levels of choline-supplemented rats were depressed slightly by ethyl trichloracetate administration, which was effective in abolishing response to Triton WR 1339. Lipoprotein lipase activity of epididymal fat pad was stimulated 60% while plasma lipoprotein was not stimulated by ethyl trichloracetate. The increased peripheral removal of low-density lipoprotein-triglyceride complex, allowing greater use to be made of existing apo-proteins, may explain the lipotropic character of the ester.

摘要

向已确定存在胆碱缺乏的大鼠皮下注射促脂剂三氯乙酸乙酯，可使它们的血浆甘油三酯升高60%，并完全消除Triton WR 1339引起的高甘油三酯血症反应。给补充胆碱的大鼠注射三氯乙酸乙酯后，其血浆甘油三酯水平略有降低，该药物能有效消除对Triton WR 1339的反应。三氯乙酸乙酯可使附睾脂肪垫的脂蛋白脂肪酶活性提高60%，而对血浆脂蛋白无刺激作用。低密度脂蛋白 - 甘油三酯复合物的外周清除增加，从而能更多地利用现有的载脂蛋白，这可能解释了该酯的促脂特性。