接受长期透析和持续性非卧床腹膜透析患者丙型肝炎病毒抗体的发生率。

Incidence of antibodies to hepatitis C virus in patients undergoing chronic dialysis and CAPD.

作者信息

Nakashima F, Sata M, Tokeshi S, Nakano H, Nakashima M, Nakashima N, Motomura K, Motomura S, Ide M, Tanikawa K

机构信息

Namazuda Clinic, Fukuoka, Department of Medicine, Kurume University School of Medicine, Japan.

出版信息

Kurume Med J. 1993;40(4):249-53. doi: 10.2739/kurumemedj.40.249.

DOI:10.2739/kurumemedj.40.249

PMID:7516454

Abstract

We measured antibodies to hepatitis C virus (anti-HCV) in patients who were receiving hemodialysis or continuous ambulatory peritoneal dialysis (CAPD). Sixty seven patients (28%) were anti-HCV positive. The anti-HCV positive frequency increased with the time of treatment with dialysis, the frequency being 50% with a dialysis period > or = 10 years. The frequency of anti-HCV positivity was similar in patients with a history of blood transfusion (48/152, 32%) and in those without this history (19/89, 21%, p > 0.05). Therefore, in addition to blood transfusion, there may be other routes of HCV infection associated with long-term dialysis. Chronic liver disease was observed in 31% (21/67) of the patients positive for anti-HCV but in only 6% (11/174) of the negative patients (p < 0.01). HCV seems to be important as a cause of chronic liver disease in dialysis patients.

摘要

我们检测了接受血液透析或持续性非卧床腹膜透析（CAPD）患者的丙型肝炎病毒抗体（抗-HCV）。67名患者（28%）抗-HCV呈阳性。抗-HCV阳性频率随透析治疗时间增加，透析时间≥10年时频率为50%。有输血史患者的抗-HCV阳性频率（48/152，32%）与无输血史患者的频率（19/89，21%，p>0.05）相似。因此，除输血外，长期透析可能还存在其他丙型肝炎病毒感染途径。抗-HCV阳性患者中31%（21/67）观察到慢性肝病，而抗-HCV阴性患者中仅6%（11/174）观察到慢性肝病（p<0.01）。丙型肝炎病毒似乎是透析患者慢性肝病的重要病因。