Cooner W H
Section of Urology, Emory University School of Medicine, Atlanta, Georgia.
Clin Invest Med. 1993 Dec;16(6):471-4.
Detection of prostate cancer can be enhanced over the level historically obtained by digital rectal examination through the combined use of serum prostate-specific antigen and digital rectal examination, followed by transrectal ultrasonic examination of the prostate and ultrasonically guided biopsy if either of the initial studies is abnormal. Use of age-specific reference ranges for prostate-specific antigen results in greater sensitivity of this serum marker in patients below the age of 60 y and greater specificity in older patients.
通过联合使用血清前列腺特异性抗原和直肠指检，相较于以往单纯直肠指检所达到的水平，前列腺癌的检测得以增强。若初始检查中有任何一项异常，则随后进行前列腺经直肠超声检查及超声引导下活检。使用针对不同年龄的前列腺特异性抗原参考范围，可使该血清标志物在60岁以下患者中具有更高的敏感性，而在老年患者中具有更高的特异性。
