Nisbet A P, Foster O J, Kingsbury A, Lees A J, Marsden C D
Parkinson's Disease Society Brain Bank, Institute of Neurology, London, UK.
Brain Res Mol Brain Res. 1994 Mar;22(1-4):329-32. doi: 10.1016/0169-328x(94)90062-0.
The distribution of NOS mRNA within human basal ganglia was investigated using in situ hybridisation histochemistry (ISHH). Greater than 95% of subthalamic nucleus neurons were NOS mRNA-positive, between 1.5% and 2% of striatal neurons were positive and scattered NOS mRNA-positive neurons were detected in the medial, but not lateral globus pallidus. Levels of NOS mRNA expression per neuron were considerably higher in the striatum than in the pallidum or subthalamus. These findings have implications for basal ganglia function and disease states.
利用原位杂交组织化学（ISHH）研究了一氧化氮合酶（NOS）mRNA在人类基底神经节中的分布。超过95%的丘脑底核神经元为NOS mRNA阳性，1.5%至2%的纹状体神经元呈阳性，在内侧苍白球检测到散在的NOS mRNA阳性神经元，而外侧苍白球未检测到。纹状体中每个神经元的NOS mRNA表达水平明显高于苍白球或丘脑底核。这些发现对基底神经节功能和疾病状态具有重要意义。
