Sussman N L, Finegold M J, Barish J P, Kelly J H
Department of Medicine, Baylor College of Medicine, Houston, Texas.
Am J Gastroenterol. 1994 Jul;89(7):1077-82.
Syncytial giant cell hepatitis (SGCH) has recently been reported to be a cause of severe hepatitis, with little chance of patient recovery without orthotopic liver transplantation. We have recently seen a patient with multisystem disease and histologic features of SGCH. Upon reaching stage IV coma, she was treated with an extracorporeal liver assist device containing 200 g of cultured liver cells. There was an immediate improvement in her galactose elimination capacity, and her own liver recovered to the point that therapy could be discontinued after 58 h. The patient recovered slowly from her multisystem disease and was discharged with mildly elevated transaminases and biochemical evidence of cholestasis. All laboratory values are normal at 2 yr, and the patient appears to have no sequelae of her disease.
合胞体巨细胞性肝炎（SGCH）最近被报道为严重肝炎的一个病因，若不进行原位肝移植，患者恢复的机会很小。我们最近遇到了一名患有多系统疾病且具有SGCH组织学特征的患者。在进入IV期昏迷后，她接受了含有200克培养肝细胞的体外肝辅助装置治疗。她的半乳糖清除能力立即得到改善，其自身肝脏恢复到在58小时后可以停止治疗的程度。患者从多系统疾病中缓慢恢复，出院时转氨酶轻度升高且有胆汁淤积的生化证据。2年时所有实验室值均正常，且患者似乎没有疾病后遗症。
