Jia Y S, Wang X A, Ju G
Department of Neurobiology, Fourth Military Medical University, Xi'an, China.
Neuroreport. 1994 Mar 21;5(7):793-6. doi: 10.1097/00001756-199403000-00014.
Peripheral axotomy of the spinal nerve and avulsion of the ventral roots have been found to induce increase in expression of nitric oxide synthase (NOS) in the spinal motor neurones and the dorsal root ganglion. The present study investigated changes of NOS, using NADPH-diaphorase (NADPH-d) reactivity as the marker, in vagal complex after axotomy in the rat. Eight days after left cervical vagotomy the NADPH-d reactivity was found to be markedly enhanced in the dorsal motor nucleus of the vagus nerve, the ambiguus nucleus, the solitary tract and the nucleus of the tractus solitarius, and the nodose ganglion. This study offers the first evidence of changes in NOS expression in cranial visceral components following axotomy.
已发现脊髓神经的外周轴突切断术和腹侧神经根撕脱术可诱导脊髓运动神经元和背根神经节中一氧化氮合酶（NOS）表达增加。本研究以还原型辅酶Ⅱ黄递酶（NADPH-d）反应性为标志物，调查大鼠轴突切断术后迷走复合体中NOS的变化。左侧颈迷走神经切断术后8天，发现迷走神经背运动核、疑核、孤束和孤束核以及结状神经节中的NADPH-d反应性显著增强。本研究首次提供了轴突切断术后颅内脏器成分中NOS表达变化的证据。
