Forster E R, Southam E
Physiological Laboratory, University of Liverpool, UK.
Neuroreport. 1993 Mar;4(3):275-8. doi: 10.1097/00001756-199303000-00012.
Nitric oxide synthase (NOS) associated with the intrinsic and vagal extrinsic innervation of the rat gastric corpus was studied in both control and neonatally capsaicin-treated animals. Nerve cell bodies and fibres of both the myenteric and sub-mucosal plexi of the gastric corpus was found to contain NOS, but were distinct from those containing VIP. NOS-positive fibres were seen innervating the circular smooth muscle layer. Stain accumulated both proximal and distal to a vagal ligature. Staining of the nucleus of the solitary tract (NTS) was associated with specific sub-nuclei. Neonatal capsaicin treatment did not alter the staining in the NTS, vagus nerve or stomach. The data presented here support the idea that NO is a non-adrenergic non-cholinergic transmitter associated with gastric function.
在对照动物和新生期用辣椒素处理的动物中，研究了与大鼠胃体固有神经和迷走神经外在神经支配相关的一氧化氮合酶（NOS）。发现胃体肌间神经丛和黏膜下神经丛的神经细胞体和纤维均含有NOS，但与含有血管活性肠肽（VIP）的细胞体和纤维不同。可见NOS阳性纤维支配环形平滑肌层。在迷走神经结扎处的近端和远端均有染色积累。孤束核（NTS）的染色与特定亚核有关。新生期辣椒素处理并未改变NTS、迷走神经或胃中的染色情况。此处呈现的数据支持以下观点：一氧化氮是一种与胃功能相关的非肾上腺素能非胆碱能递质。
