Taylor C P
Department of Neuroscience Pharmacology, Parke-Davis Research, Division of Warner-Lambert Co., Ann Arbor, Michigan 48105.
Neurology. 1994 Jun;44(6 Suppl 5):S10-6; discussion S31-2.
Significant advances have been made in understanding the molecular and cellular mechanisms underlying seizure disorders and the actions of antiepileptic drugs. Agents with new mechanisms of action or enhanced activity via known mechanisms might provide improved seizure control or more selective therapy for specific epilepsies. Gabapentin is a new antiepileptic drug that is structurally similar to the neurotransmitter GABA and the endogenous amino acid L-leucine. The mechanism of action of gabapentin is not fully understood, but its distinct profile of anticonvulsant activity in animal seizure models and its lack of activity at many drug binding sites associated with other antiepileptic drugs indicate that its mechanism of action is novel.
在理解癫痫疾病的分子和细胞机制以及抗癫痫药物的作用方面已经取得了重大进展。具有新作用机制或通过已知机制增强活性的药物可能会改善癫痫控制或为特定癫痫提供更具选择性的治疗。加巴喷丁是一种新型抗癫痫药物，其结构与神经递质γ-氨基丁酸（GABA）和内源性氨基酸L-亮氨酸相似。加巴喷丁的作用机制尚未完全明确，但其在动物癫痫模型中独特的抗惊厥活性特征以及在许多与其他抗癫痫药物相关的药物结合位点缺乏活性，表明其作用机制是新颖的。
