细胞因子外表面的常见结构模式。

Common structural patterns of cytokine outer surfaces.

作者信息

Denesyuk A I, Zav'yalov V P, Korpela T

机构信息

Institute of Immunology, Moscow Region, Russia.

出版信息

Biochem Biophys Res Commun. 1994 Jun 30;201(3):1396-400. doi: 10.1006/bbrc.1994.1858.

DOI:10.1006/bbrc.1994.1858

PMID:7517669

Abstract

Schemes of the four-helix bundle surfaces of interleukin-2, -4, -5, granulocyte/macrophage-, granulocyte-, macrophage-colony-stimulating factor, interferon-beta, -gamma and growth hormone were designed. All cytokines appeared to have the structurally similar "holes" on the surfaces. They were suggested to serve as a part of the main receptor-binding sites.

摘要

设计了白细胞介素 -2、-4、-5、粒细胞/巨噬细胞集落刺激因子、粒细胞集落刺激因子、巨噬细胞集落刺激因子、干扰素 -β、-γ 和生长激素的四螺旋束表面示意图。所有细胞因子表面似乎都有结构相似的“空洞”。这些“空洞”被认为是主要受体结合位点的一部分。