Denesyuk A I, Zav'yalov V P, Korpela T
Institute of Immunology, Moscow Region, Russia.
Biochem Biophys Res Commun. 1994 Jun 30;201(3):1401-5. doi: 10.1006/bbrc.1994.1859.
On the basis of crystallographic data, the alpha-helices of interferon-beta as well as each domain of interferon-gamma are located in two layers. This results in a different contribution from the amino acids placing in the middle and border alpha-helices of the layer to the hydrophobic core of the molecule. A close analysis of the structure of dimeric interleukin-5 shows related arrangements of alpha-helices. The full schemes of the interhelix contacts of interferons-beta, -gamma, and dimeric interleukin-5 were constructed. Schemes for interleukin-5 show that extension of helices correlates with the dimer topology.
基于晶体学数据，干扰素-β的α-螺旋以及干扰素-γ的每个结构域都位于两层中。这导致位于该层中间和边缘α-螺旋的氨基酸对分子疏水核心的贡献不同。对二聚体白细胞介素-5结构的仔细分析显示了α-螺旋的相关排列。构建了干扰素-β、-γ和二聚体白细胞介素-5的螺旋间接触的完整示意图。白细胞介素-5的示意图表明螺旋的延伸与二聚体拓扑结构相关。
