Ohno K, Takeda N, Kiyama H, Kubo T, Tohyama M
Department of Otolaryngology, Osaka University Medical School, Japan.
Brain Res. 1994 Apr 25;644(1):135-43. doi: 10.1016/0006-8993(94)90356-5.
The origins of the vestibular and cochlear efferent systems lie in the lower brainstem and innervate the labyrinth. In the present study we investigated the changes in galanin-like immunoreactivity (GAL-IR) in the vestibular and cochlear efferent neurons in control and labyrinthectomized rats. In control animals, no GAL-IR was noticed in these neurons. However, in response to unilateral labyrinthectomy, similar GAL-IR was bilaterally expressed in the two systems. GAL-immunostained cells appeared on postoperative day 3 and reached a peak of intensity and number at postoperative week 2. Retrograde tracing by fluorogold combined with GAL immunohistochemistry demonstrated that, except for the cells of the contralateral lateral superior olivary nucleus (LSO), GAL-IR neurons project into the lesioned labyrinth.
前庭和耳蜗传出系统起源于脑桥下部，支配内耳迷路。在本研究中，我们调查了对照大鼠和迷路切除大鼠的前庭和耳蜗传出神经元中甘丙肽样免疫反应性（GAL-IR）的变化。在对照动物中，这些神经元未观察到GAL-IR。然而，单侧迷路切除术后，两个系统均出现双侧相似的GAL-IR表达。GAL免疫染色细胞在术后第3天出现，并在术后第2周达到强度和数量的峰值。荧光金逆行追踪结合GAL免疫组化显示，除对侧外侧上橄榄核（LSO）的细胞外，GAL-IR神经元投射到受损的迷路。
