Carson C W, Beall L D, Hunder G G, Johnson C M, Newman W
Department of Medicine, Mayo Clinic/Foundation, Rochester, MN.
J Rheumatol. 1994 Apr;21(4):605-11.
To investigate the hypothesis that soluble E-selectin (sE-selectin) may be detected in synovial fluid (SF) and play a role in inflammatory arthritis.
We used a sandwich ELISA to measure sE-selectin in the SF of 58 patients with rheumatoid arthritis (RA), 9 with psoriatic arthritis (PsA), 30 with osteoarthritis (OA), 13 with gout, and 9 with calcium pyrophosphate dihydrate crystal deposition disease (CPPD).
SF sE-selectin values in RA (mean 1.49 ng/ml, 0.18-3.90) and PsA (mean 1.36 ng/ml, 0.88-2.31) were significantly higher than those with OA (mean 0.83 ng/ml, 0.00-1.83), gout (mean 1.04 ng/ml, 0.11-3.42), or CPPD (mean 0.80 ng/ml, 0.20-1.47). Elevated SF sE-selectin was associated with elevated serum sE-selectin, erythrocyte sedimentation rate, and SF white blood cell count.
Our findings suggest that endothelial cell activation and E-selectin may contribute to the development of inflammatory processes.
探讨在滑液（SF）中可检测到可溶性E选择素（sE-selectin）并在炎性关节炎中发挥作用这一假说。
我们采用夹心酶联免疫吸附测定法（ELISA）检测了58例类风湿关节炎（RA）患者、9例银屑病关节炎（PsA）患者、30例骨关节炎（OA）患者、13例痛风患者和9例焦磷酸钙双水合物晶体沉积病（CPPD）患者滑液中的sE-selectin。
RA患者（平均1.49 ng/ml，0.18 - 3.90）和PsA患者（平均1.36 ng/ml，0.88 - 2.31）的滑液sE-selectin值显著高于OA患者（平均0.83 ng/ml，0.00 - 1.83）、痛风患者（平均1.04 ng/ml，0.11 - 3.42）或CPPD患者（平均0.80 ng/ml，0.20 - 1.47）。滑液sE-selectin升高与血清sE-selectin升高、红细胞沉降率及滑液白细胞计数升高相关。
我们的研究结果表明，内皮细胞活化和E选择素可能参与了炎症过程的发展。
