Hasui Y, Marutsuka K, Asada Y, Ide H, Nishi S, Osada Y
Department of Urology, Miyazaki Medical College, Japan.
Prostate. 1994 Aug;25(2):91-6. doi: 10.1002/pros.2990250206.
The relationship between the serum values of prostate specific antigen (PSA) and the extent of histological prostatitis was investigated in 42 patients undergoing transurethral resection of the prostate for benign hyperplasia (BPH) without clinical evidence of prostatitis. Histological prostatitis was divided into three groups: acute, chronic-active, and chronic-inactive inflammation. The extent of histological prostatitis was expressed as the number of prostatic acinar and ductal glands with inflammatory infiltrate per total number of glands (%). The serum PSA values significantly correlated with the extent of acute and chronic-active prostatitis (correlation coefficient r = 0.765 and 0.656, P < 0.01). A relationship between PSA values and the extent of chronic-inactive prostatitis was not found. In the immunohistochemical study, prostatic epithelial cells with acute and chronic-active inflammation showed negative staining for PSA antigen. These results indicate that histological acute and chronic-active prostatitis is considered an important factor for inducing the high increase in serum PSA values via the leak phenomenon.
在42例因良性前列腺增生（BPH）接受经尿道前列腺切除术且无前列腺炎临床证据的患者中，研究了前列腺特异性抗原（PSA）血清值与组织学前列腺炎程度之间的关系。组织学前列腺炎分为三组：急性、慢性活动性和慢性非活动性炎症。组织学前列腺炎的程度表示为有炎性浸润的前列腺腺泡和导管腺数量占腺体总数的百分比（%）。血清PSA值与急性和慢性活动性前列腺炎的程度显著相关（相关系数r = 0.765和0.656，P < 0.01）。未发现PSA值与慢性非活动性前列腺炎程度之间的关系。在免疫组织化学研究中，急性和慢性活动性炎症的前列腺上皮细胞对PSA抗原呈阴性染色。这些结果表明，组织学急性和慢性活动性前列腺炎被认为是通过渗漏现象导致血清PSA值大幅升高的一个重要因素。
