Bello M J, de Campos J M, Kusak M E, Vaquero J, Sarasa J L, Pestaña A, Rey J A
Instituto de Investigaciones Biomédicas (CSIC), Madrid, Spain.
Genes Chromosomes Cancer. 1994 Apr;9(4):296-8. doi: 10.1002/gcc.2870090411.
Next to chromosome 22 anomalies, deletions of the short arm of chromosome 1 have previously been described as the most frequent alteration detected by cytogenetic analysis of meningiomas. To determine the incidence of these deletions, we have analyzed a series of 50 meningiomas for the loss of alleles at four chromosome 1 loci. Thirteen samples displayed LOH for the markers studied; in one instance, the results were compatible with loss of the entire chromosome 1, whereas in the other 12 samples deletions of the short arm were observed. Eleven of the meningiomas had previously been shown to have loss of alleles on chromosome 22, and 12 of them were characterized by increased tumor aggressiveness. These findings suggest that deletion of Ip (or the alteration of a locus located there) might represent a secondary, but nonrandom alteration in meningiomas, perhaps contributing to meningioma tumor progression.
除了22号染色体异常外，1号染色体短臂缺失先前已被描述为通过脑膜瘤细胞遗传学分析检测到的最常见改变。为了确定这些缺失的发生率，我们分析了一系列50例脑膜瘤在4个1号染色体位点上等位基因的缺失情况。13个样本在所研究的标记上显示杂合性缺失；其中1例结果与整个1号染色体缺失相符，而在其他12个样本中观察到短臂缺失。其中11例脑膜瘤先前已显示22号染色体上等位基因缺失，且其中12例具有肿瘤侵袭性增加的特征。这些发现表明，1p缺失（或位于该区域的一个位点的改变）可能代表脑膜瘤中的一种继发性但非随机的改变，可能促进脑膜瘤的肿瘤进展。
