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Loss over 5% of chromosome 1p is a clinically relevant and applicable cut-off for increased risk of recurrence in meningioma.

作者信息

Maas Sybren L N, Hielscher Thomas, Sievers Philipp, Hovestadt Volker, Suwala Abigail K, Acker Till, Weller Michael, Preusser Matthias, Herold-Mende Christel, Wick Wolfgang, von Deimling Andreas, Berghaus Natalie, Sahm Felix

机构信息

Department of Pathology, Leiden University Medical Center, Leiden, Netherlands.

Department of Pathology, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, The Netherlands.

出版信息

Acta Neuropathol. 2024 Aug 8;148(1):17. doi: 10.1007/s00401-024-02777-z.

DOI:10.1007/s00401-024-02777-z
PMID:39115604
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11310275/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ba7/11310275/e81b11643655/401_2024_2777_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ba7/11310275/e81b11643655/401_2024_2777_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ba7/11310275/e81b11643655/401_2024_2777_Fig1_HTML.jpg

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Detection of chromosome 1p deletion using FISH on meningioma touch imprints suggest a region outside chromosome 22 as important in tumor recurrence.利用荧光原位杂交技术（FISH）对脑膜瘤压片进行1号染色体缺失检测，结果表明22号染色体以外的一个区域在肿瘤复发中具有重要作用。
Minerva Med. 2003 Feb;94(1):51-6.
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Loss of 1p in recurrent meningiomas. a comparative study in successive recurrences by cytogenetics and fluorescence in situ hybridization.复发性脑膜瘤中1p缺失：通过细胞遗传学和荧光原位杂交技术对连续复发病例的比较研究
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本文引用的文献

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Meningioma: International Consortium on Meningiomas consensus review on scientific advances and treatment paradigms for clinicians, researchers, and patients.脑膜瘤：脑膜瘤国际联合会关于临床医生、研究人员和患者的科学进展和治疗模式的共识综述。
Neuro Oncol. 2024 Oct 3;26(10):1742-1780. doi: 10.1093/neuonc/noae082.
2
Independent prognostic impact of DNA methylation class and chromosome 1p loss in WHO grade 2 and 3 meningioma undergoing adjuvant high-dose radiotherapy: comprehensive molecular analysis of EORTC 22042-26042.DNA甲基化类别和1号染色体缺失对接受辅助高剂量放疗的世界卫生组织2级和3级脑膜瘤的独立预后影响：欧洲癌症研究与治疗组织22042-26042的综合分子分析
Acta Neuropathol. 2023 Dec;146(6):837-840. doi: 10.1007/s00401-023-02642-5. Epub 2023 Oct 19.
3
Testing Meningiomas With Methylation Arrays: Insights and Recommendations From a Large Single-Centre Study.
使用甲基化阵列检测脑膜瘤：一项大型单中心研究的见解与建议
Neuropathol Appl Neurobiol. 2025;51(3):e70018. doi: 10.1111/nan.70018.
4
Chromosome 1p Loss and 1q Gain for Grading of Meningioma.用于脑膜瘤分级的1号染色体短臂缺失和1号染色体长臂增加
JAMA Oncol. 2025 Apr 3. doi: 10.1001/jamaoncol.2025.0329.
5
Refining prognostic stratification of atypical meningiomas: significance of chromosome 1p deletion and brain invasion.优化非典型脑膜瘤的预后分层：1p染色体缺失和脑侵袭的意义
Acta Neuropathol Commun. 2025 Mar 6;13(1):50. doi: 10.1186/s40478-025-01973-6.
6
Malignant Transformation of Meningiomas.脑膜瘤的恶性转化
J Cancer. 2025 Feb 10;16(5):1684-1693. doi: 10.7150/jca.105024. eCollection 2025.
Clinical implementation of integrated molecular-morphologic risk prediction for meningioma.脑膜瘤综合分子-形态学风险预测的临床实施。
Brain Pathol. 2023 May;33(3):e13132. doi: 10.1111/bpa.13132. Epub 2022 Nov 14.
4
Integrated Molecular-Morphologic Meningioma Classification: A Multicenter Retrospective Analysis, Retrospectively and Prospectively Validated.整合分子形态学脑膜瘤分类：多中心回顾性和前瞻性验证研究。
J Clin Oncol. 2021 Dec 1;39(34):3839-3852. doi: 10.1200/JCO.21.00784. Epub 2021 Oct 7.
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DNA methylation-based classification and grading system for meningioma: a multicentre, retrospective analysis.基于 DNA 甲基化的脑膜瘤分类和分级系统：一项多中心回顾性分析。
Lancet Oncol. 2017 May;18(5):682-694. doi: 10.1016/S1470-2045(17)30155-9. Epub 2017 Mar 15.
8
Triple approach for diagnosis and grading of meningiomas: histology, morphometry of Ki-67/Feulgen stainings, and cytogenetics.脑膜瘤诊断与分级的三重方法：组织学、Ki-67/福尔根染色的形态计量学及细胞遗传学
Acta Neurochir (Wien). 1995;137(3-4):174-81. doi: 10.1007/BF02187190.
9
Allelic loss at 1p is associated with tumor progression of meningiomas.1p等位基因缺失与脑膜瘤的肿瘤进展相关。
Genes Chromosomes Cancer. 1994 Apr;9(4):296-8. doi: 10.1002/gcc.2870090411.
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Chromosomal consitution of meningiomas.脑膜瘤的染色体组成。
Nature. 1967 Oct 7;216(5110):84-5. doi: 10.1038/216084a0.