Bartsch U, Faissner A, Trotter J, Dörries U, Bartsch S, Mohajeri H, Schachner M
Department of Neurobiology, Swiss Federal Institute of Technology, Zürich.
J Neurosci. 1994 Aug;14(8):4756-68. doi: 10.1523/JNEUROSCI.14-08-04756.1994.
The molecular determinants controlling the topographically restricted distribution of neural cells in the mammalian CNS are largely unknown. In the mouse, myelin-forming oligodendrocytes are differentially distributed along retinal ganglion cell axons. These axons are myelin free intraretinally and in the most proximal (i.e., retinal) part of the optic nerve, but become myelinated in the distal (i.e., chiasmal) part of the optic nerve. Tenascin protein and mRNA are detectable in increased amounts at the retinal end of the developing optic nerve before the arrival of oligodendrocyte progenitor cells and are restricted to this region in the adult optic nerve. Tenascin is a nonadhesive substrate for oligodendrocytes and their progenitor cells in vitro when offered as a substrate in choice with polyornithine. These observations suggest that tenascin is critical for the establishment and maintenance of the restricted distribution of myelin-forming oligodendrocytes along retinal ganglion cell axons of the mouse.
控制哺乳动物中枢神经系统中神经细胞拓扑学上受限分布的分子决定因素在很大程度上尚不清楚。在小鼠中，形成髓鞘的少突胶质细胞沿视网膜神经节细胞轴突呈差异分布。这些轴突在视网膜内以及视神经最靠近视网膜的近端部分是无髓鞘的，但在视神经的远端（即交叉的）部分会形成髓鞘。在少突胶质细胞祖细胞到达之前，在发育中的视神经的视网膜端可检测到腱生蛋白的蛋白质和信使核糖核酸的量增加，并且在成年视神经中局限于该区域。当与聚鸟氨酸一起作为底物提供时，腱生蛋白在体外是少突胶质细胞及其祖细胞的非粘附性底物。这些观察结果表明，腱生蛋白对于在小鼠视网膜神经节细胞轴突上形成髓鞘的少突胶质细胞的受限分布的建立和维持至关重要。
