Hatakeyama S, Satoh M, Yoshimura N, Otsu T
Department of Oral Pathology, School of Dentistry, Iwate Medical University, Japan.
J Oral Pathol Med. 1994 May;23(5):232-6. doi: 10.1111/j.1600-0714.1994.tb01119.x.
The localization of bone morphogenetic protein (BMP)-1, -2, -3 and transforming growth factor (TGF)-beta in normal salivary gland and pleomorphic adenoma of the salivary gland has been examined immunocytochemically. Tumor cells with BMP immunostaining in pleomorphic adenoma were associated with some solid cellular and tubuloglandular patterns, and with stellate cells in the myxoid area. In addition, in the chondroid area of three pleomorphic adenomas, chondrocyte-like cells were positive for BMPs. It is speculated that BMPs secreted by the tumor cells play a role in the formation of the chondroid component in pleomorphic adenoma by inducing some tumor cells, probably neoplastic myoepithelial cells, to differentiate to chondrocytes by metaplastic change. No tumor cells specifically immunostained with TGF-beta were found. TGF-beta was positive in fibrous and hyalinized stroma. In the submandibular gland, only anti-BMP-1 antibody specifically reacted to apical portions of degenerated serous acinar cells.
采用免疫细胞化学方法检测了骨形态发生蛋白（BMP）-1、-2、-3以及转化生长因子（TGF）-β在正常涎腺和涎腺多形性腺瘤中的定位。多形性腺瘤中出现BMP免疫染色的肿瘤细胞与一些实性细胞及小管腺泡样结构有关，也与黏液样区域的星状细胞有关。此外，在3例多形性腺瘤的软骨样区域，类软骨细胞对BMP呈阳性反应。据推测，肿瘤细胞分泌的BMP通过诱导一些肿瘤细胞（可能是肿瘤性肌上皮细胞）发生化生改变分化为软骨细胞，从而在多形性腺瘤软骨样成分的形成中发挥作用。未发现肿瘤细胞对TGF-β呈特异性免疫染色。TGF-β在纤维性和玻璃样变的基质中呈阳性。在下颌下腺中，只有抗BMP-1抗体特异性地与变性浆液性腺泡细胞的顶端部分发生反应。
