Mizuki Y, Suetsugi M, Ushijima I, Yamada M
Department of Neuropsychiatry, Yamaguchi University School of Medicine, Ube, Japan.
Methods Find Exp Clin Pharmacol. 1994 May;16(4):291-300.
Fmtheta is a distinct theta activity in the frontal midline area that appears during performance of mental tasks. It is suggested that relief from anxiety might be reflected in the appearance of Fmtheta. In the present study, the anxiolytic effects of buspirone were investigated using 24 male university students with (Fmtheta group, n = 12) and without (non-Fmtheta group, n = 12) Fmtheta. The subjects were given placebo, buspirone 5 mg and 15 mg in a double-blind, crossover design. Blood samples were obtained, scores were made on the State Trait Anxiety Inventory (STAI), and EEGs were recorded before and during performance of an arithmetic addition. The test was repeated twice: before and 1 h after drug administration. In the Fmtheta group, buspirone dose-dependently produced a decrease in plasma 5-HT and 5-HIAA concentrations and in state anxiety scores and an increase in Fmtheta amounts. In the non-Fmtheta group, however, there were no differences in these items except for 5-HT concentration before and after buspirone administration. These results suggest that anxiety in the Fmtheta group is mainly correlated with 5-HT1A receptor function, and that buspirone may have anxiolytic effects in patients with reactive anxiety but not those with endogenous anxiety.
额中线θ波（Fmtheta）是在执行心理任务时出现在额中线区域的一种独特的θ波活动。有人认为焦虑缓解可能反映在Fmtheta的出现上。在本研究中，使用24名男性大学生（有Fmtheta组，n = 12；无Fmtheta组，n = 12）研究了丁螺环酮的抗焦虑作用。受试者在双盲、交叉设计中分别服用安慰剂、5毫克和15毫克丁螺环酮。采集血样，使用状态-特质焦虑量表（STAI）评分，并在进行加法运算前和运算过程中记录脑电图。测试重复两次：给药前和给药后1小时。在有Fmtheta组中，丁螺环酮剂量依赖性地使血浆5-羟色胺（5-HT）和5-羟吲哚乙酸（5-HIAA）浓度以及状态焦虑评分降低，Fmtheta量增加。然而，在无Fmtheta组中，除丁螺环酮给药前后的5-HT浓度外，这些指标没有差异。这些结果表明，有Fmtheta组的焦虑主要与5-HT1A受体功能相关，丁螺环酮可能对反应性焦虑患者有抗焦虑作用，但对内源性焦虑患者无效。
