Okui T, Hayashi M, Endoh D, Sato F, Kasai N, Watanabe T, Namioka S
Hokkaido Institute of Public Health, Sapporo, Japan.
Mutat Res. 1994 Aug;324(4):165-9. doi: 10.1016/0165-7992(94)90015-9.
LEC strain rats, which have been known to develop hereditarily spontaneous fulminant hepatitis 4 to 5 months after birth, are highly sensitive to whole-body X-irradiation when compared to WKAH strain rats. The present results showed that the frequencies of all types of chromosome aberrations induced by X-irradiation in the bone marrow cells of LEC rats were approximately 2- to 3-fold higher than those of WKAH rats, though no significant difference was observed in the frequency of spontaneous chromosome aberrations between LEC and WKAH rats.
LEC品系大鼠在出生后4至5个月会遗传性地自发发生暴发性肝炎，与WKAH品系大鼠相比，它们对全身X射线照射高度敏感。目前的结果表明，X射线诱导的LEC大鼠骨髓细胞中各类染色体畸变的频率比WKAH大鼠高约2至3倍，尽管LEC大鼠和WKAH大鼠的自发染色体畸变频率未观察到显著差异。
